Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer

RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …

Cell-surface-retained peptide additives for the cytosolic delivery of functional proteins

JVV Arafiles, J Franke, L Franz… - Journal of the …, 2023 - ACS Publications
The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Cell-penetrating peptides and transportan

Ü Langel - Pharmaceutics, 2021 - mdpi.com
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-
penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery …

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

GA Gonzales, S Huang, L Wilkinson, JA Nguyen… - Science …, 2024 - science.org
Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL)
responses against extracellular pathogens and tumors. This is achieved through a process …

Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

E Trofimenko, G Grasso, M Heulot, N Chevalier… - Elife, 2021 - elifesciences.org
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …

[HTML][HTML] Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides

M Serulla, P Anees, A Hallaj, E Trofimenko… - European Journal of …, 2023 - Elsevier
Cell-penetrating peptides (CPPs) are short (< 30 amino acids), generally cationic, peptides
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …

Increase in anionic Fe 3 O 4 nanoparticle-induced membrane poration and vesicle deformation due to membrane potential–an experimental study

M Moniruzzaman, MAS Karal, MA Wadud… - Physical Chemistry …, 2023 - pubs.rsc.org
The membrane potential plays a significant role in various cellular processes while
interacting with membrane active agents. So far, all the investigations of the interaction of …

Effects of membrane potentials on the electroporation of giant unilamellar vesicles

MA Wadud, MAS Karal, M Moniruzzaman… - PLoS …, 2023 - journals.plos.org
Living organisms maintain a resting membrane potential, which plays an important role in
various biophysical and biological processes. In the context of medical applications …

Approaches for evaluation of novel CPP-based cargo delivery systems

L Porosk, Ü Langel - Frontiers in Pharmacology, 2022 - frontiersin.org
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …