Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Cell-penetrating peptides (CPPs) as therapeutic and diagnostic agents for cancer
RA Bottens, T Yamada - Cancers, 2022 - mdpi.com
Simple Summary Crossing biological barriers is often required for drug delivery. Cell-
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …
penetrating peptides (CPPs) are short strands of amino acids that have been widely used as …
Cell-surface-retained peptide additives for the cytosolic delivery of functional proteins
JVV Arafiles, J Franke, L Franz… - Journal of the …, 2023 - ACS Publications
The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …
Cell-penetrating peptides and transportan
Ü Langel - Pharmaceutics, 2021 - mdpi.com
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-
penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery …
penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery …
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
GA Gonzales, S Huang, L Wilkinson, JA Nguyen… - Science …, 2024 - science.org
Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL)
responses against extracellular pathogens and tumors. This is achieved through a process …
responses against extracellular pathogens and tumors. This is achieved through a process …
Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
E Trofimenko, G Grasso, M Heulot, N Chevalier… - Elife, 2021 - elifesciences.org
Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …
[HTML][HTML] Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides
Cell-penetrating peptides (CPPs) are short (< 30 amino acids), generally cationic, peptides
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …
Increase in anionic Fe 3 O 4 nanoparticle-induced membrane poration and vesicle deformation due to membrane potential–an experimental study
The membrane potential plays a significant role in various cellular processes while
interacting with membrane active agents. So far, all the investigations of the interaction of …
interacting with membrane active agents. So far, all the investigations of the interaction of …
Effects of membrane potentials on the electroporation of giant unilamellar vesicles
Living organisms maintain a resting membrane potential, which plays an important role in
various biophysical and biological processes. In the context of medical applications …
various biophysical and biological processes. In the context of medical applications …
Approaches for evaluation of novel CPP-based cargo delivery systems
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …