Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific
internalisation of large amounts of extracellular fluid, solutes and membrane in large …

Macropinocytosis is a regulated form of endocytosis that mediates the non‐selective uptake
of solute molecules, nutrients and antigens. It is an actin‐dependent process initiated from …

The transfer of antigens from oligodendrocytes to immune cells has been implicated in the
pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility
to inhibitors of Na+/H+ exchange. Yet, the functional relationship between Na+/H+ exchange …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

It is easy to be fascinated by dendritic cells (DCs), not only because of their pivotal role in the
immune response, but also because of the elegance with which they perform their tasks …

There are numerous ways that endocytic cargo molecules may be internalized from the
surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of …