The COVID-19 pandemic now totaling 13,000,000 cases and over 571,000 deaths has
continued to teach the medical, scientific and lay communities about viral infectious disease …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …

Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …

Cerebral malaria is a life-threatening complication of malaria caused by the parasite
Plasmodium falciparum. The growing problem of drug resistance and the dearth of new …

Thrombomodulin (TM) is a thrombin receptor on endothelial cells that is involved in
promoting activation of the anticoagulant protein C pathway during blood coagulation. TM …

Protease‐activated receptors (PARs) are a family of highly conserved G protein‐coupled
receptors (GPCRs) that respond to extracellular proteases via a unique proteolysis …

The G protein-coupled receptor (GPCR) protease-activated receptor 1 (PAR1) is a
therapeutic target that was originally pursued with the aim of restricting platelet activation …

Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C
(APC) is protective in several animal models of disease, and APC has been used clinically …