[HTML][HTML] Proactive and reactive roles of TGF-β in EMT-induced plasticity
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …
Forkhead box transcription factors: double-edged swords in cancer
M Castaneda, P Hollander, SA Mani - Cancer research, 2022 - AACR
A plethora of treatment options exist for cancer therapeutics, but many are limited by side
effects and either intrinsic or acquired resistance. The need for more effective targeted …
effects and either intrinsic or acquired resistance. The need for more effective targeted …
Spatial and Temporal Relationship between Epithelial–Mesenchymal Transition (EMT) and Stem Cells in Cancer
P Den Hollander, JJ Maddela, SA Mani - Clinical chemistry, 2024 - academic.oup.com
Background Epithelial–mesenchymal transition (EMT) is often linked with carcinogenesis.
However, EMT is also important for embryo development and only reactivates in cancer …
However, EMT is also important for embryo development and only reactivates in cancer …
Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain
The over-expression of Polo-like kinase-1 (PLK1) is associated with cancer prognosis due to
its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal …
its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal …
The role of polo-like kinase 1 in regulating the forkhead box family transcription factors
XTR Moore, L Gheghiani, Z Fu - Cells, 2023 - mdpi.com
Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation
substrates through which it regulates many biological processes, including mitosis …
substrates through which it regulates many biological processes, including mitosis …
Molecular targets and therapeutics in chemoresistance of triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a specific subtype of breast cancer (BC), which
shows immunohistochemically negative expression of hormone receptor ie, Estrogen …
shows immunohistochemically negative expression of hormone receptor ie, Estrogen …
Emerging roles and mechanisms of FOXC2 in cancer
T Wang, L Zheng, Q Wang, YW Hu - Clinica chimica acta, 2018 - Elsevier
Forkhead box protein C2 (FOXC2), a transcription factor of the forkhead/winged-helix family,
is required for embryonic and prenatal development. FOXC2 acts as a crucial modulator …
is required for embryonic and prenatal development. FOXC2 acts as a crucial modulator …
FOXC2 promotes oxaliplatin resistance by inducing epithelial-mesenchymal transition via MAPK/ERK signaling in colorectal cancer
Background Chemoresistance is a major obstacle to improving the survival rate of colorectal
cancer (CRC) patients. Forkhead box protein C2 (FOXC2), a member of the forkhead box …
cancer (CRC) patients. Forkhead box protein C2 (FOXC2), a member of the forkhead box …
[HTML][HTML] Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and
stem-like attributes, facilitating metastasis, a leading cause of cancer-related mortality …
stem-like attributes, facilitating metastasis, a leading cause of cancer-related mortality …
Members of FOX family could be drug targets of cancers
J Wang, W Li, Y Zhao, DE Kang, W Fu, X Zheng… - Pharmacology & …, 2018 - Elsevier
FOX families play important roles in biological processes, including metabolism,
development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here …
development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here …