Time for united action on depression: a Lancet–World Psychiatric Association Commission
Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …
in the way it becomes known to the self—to the mediating intellect—as to verge close to …
Molecular pathways of major depressive disorder converge on the synapse
GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …
molecular etiology. Extensive studies at different molecular levels point to a high complexity …
Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Annual Research Review: Sex, gender, and internalizing conditions among adolescents in the 21st century–trends, causes, consequences
Internalizing conditions of psychopathology include depressive and anxiety disorders; they
most often onset in adolescence, are relatively common, and contribute to significant …
most often onset in adolescence, are relatively common, and contribute to significant …
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature …, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder
Biobanks often contain several phenotypes relevant to diseases such as major depressive
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …