Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various …

Neutrophil extracellular traps (NETs) are released as neutrophils die in vitro in a process
requiring hours, leaving a temporal gap that invasive microbes may exploit. Neutrophils …

Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts
that proliferate and differentiate to generate red cells. Although this process has been …

With increasing worldwide demand for safe blood, there is much interest in generating red
blood cells in vitro as an alternative clinical product. However, available methods for in vitro …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …

Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and
pathological conditions, implying that they may play important biological functions. Here we …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Human erythropoiesis is a complex multistep process that involves the differentiation of early
erythroid progenitors to mature erythrocytes. Here we show that it is feasible to differentiate …