The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Primary episodic ataxias are autosomal dominant channelopathies that manifest as attacks
of imbalance and incoordination. Mutations in two genes, KCNA1 and CACNA1A, cause the …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

▪ Abstract Mutations in over 70 genes now define biological pathways leading to epilepsy,
an episodic dysrhythmia of the cerebral cortex marked by abnormal network …

It is well established that idiopathic generalized epilepsies (IGEs) show a polygenic origin
and may arise from dysfunction of various types of voltage-and ligand-gated ion channels …

It is just over a decade since the discovery of the first human epilepsy associated ion
channel gene mutation. Since then mutations in at least 25 different genes have been …

The idiopathic generalized epilepsies encompass a class of epileptic seizure types that
exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have …

Several inherited human neurological disorders can be caused by mutations in genes
encoding Ca 2+ channel subunits. This review deals with known human and mouse calcium …

Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …

The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave
seizures and cerebellar ataxia. A mutation in Cacna2d2, the gene encoding the α2δ-2 …