Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian
homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1) …

Caspases, a family of cysteine-dependent aspartate-specific proteases, are central to the
maintenance of cellular and organismal homoeostasis by functioning as key mediators of …

The global occurrence of organic UV filters in the marine environment is of increasing
ecotoxicological concern. Here we assessed the toxicity of UV filters ensulizole and …

Genomic instability underlies genesis and the development of various types of cancer.
During tumorigenesis, cancer initiating cells assume a set of features, which allow them to …

Microglia, the resident immune cells of the brain, can acquire various cell phenotypes based
on their location and current role. This level of plasticity is required to fulfil the vast variety of …

Background Non-small-cell lung cancer (NSCLC) has one of the highest mortality rates
among cancers worldwide, with a poor prognosis. Previous studies have reported that …

Alzheimer's disease (AD) was first described by Alois Alzheimer over 100 years ago, but
there is still no overarching theory that can explain its cause in detail. There are also no …

Most caspases can be positioned unambiguously within the regulated cell death networks of
apoptosis and pyroptosis, but the role of caspase-2, a highly conserved protease within the …

Abstract Caspase-2 (Casp2) is a promising therapeutic target in several human diseases,
including nonalcoholic steatohepatitis (NASH) and Alzheimer's disease (AD). However, the …

Targeting amyloid-β plaques and tau tangles has failed to provide effective treatments for
Alzheimer's disease and related dementias (ADRD). A more fruitful pathway to ADRD …