The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Abstract Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme
degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and …

A decline in capillary density and blood flow with age is a major cause of mortality and
morbidity. Understanding why this occurs is key to future gains in human health. NAD …

Objectives—Pulmonary hypertension (PH) is a process of lung vascular remodeling, which
can lead to right heart dysfunction and significant morbidity. The underlying mechanisms …

Autophagy is a highly conserved catabolic process involving autolysosomal degradation of
cellular components, including protein aggregates, damaged organelles (such as …

Sepsis is a systemic inflammatory response to infection and a major cause of death
worldwide. Because specific therapies to treat sepsis are limited, and underlying …

In neonates, hyperoxia or positive pressure ventilation causes continued lung injury
characterized by simplified vascularization and alveolarization, which are the hallmarks of …

Administration of supplemental oxygen remains a critical clinical intervention for survival of
preterm infants with respiratory failure. However, prolonged exposure to hyperoxia can …

High levels of inspired oxygen, hyperoxia, are frequently used in patients with acute
respiratory failure. Hyperoxia can exacerbate acute respiratory failure, which has high …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease with dismal
prognosis and no cure. The potential role of the ubiquitously expressed SH2 domain …