Macroautophagy (hereafter autophagy), literally defined as a type of self-eating, is a
dynamic cellular process in which cytoplasm is sequestered within a unique compartment …

Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of
cellular processes, including responses to nutrient availability and composition, stress …

Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …

Abstract Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-
induced defects in autophagic flux may contribute to an impaired ability for neurological …

Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …

In eukaryotes, autophagy helps maintain cellular homeostasis by degrading and recycling
cytoplasmic materials via a tightly regulated pathway. Over the past few decades, significant …

Mycobacterium tuberculosis (Mtb) is responsible for approximately 1.5 million deaths each
year. Though 10% of patients develop tuberculosis (TB) after infection, 90% of these …

Background: Increasing evidence suggests that acute traumatic spinal cord injury (SCI)-
induced defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to …

The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …

Acetylation is an important posttranslational modification (PTM) that regulates almost all core
processes of autophagy in yeast and mammals. However, the role of protein acetylation in …