The inflammatory response involves the activation of several cell types to fight insults
caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand …

Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

The pentose phosphate pathway, one of the main antioxidant cellular defense systems, has
been related for a long time almost exclusively to its role as a provider of reducing power …

Astrocyte-mediated inflammation is associated with degenerative pathologies such as
Alzheimer's and Parkinson's diseases and multiple sclerosis. The acute inflammation and …

Re-programming of metabolic pathways is a hallmark of pathological changes in cancer
cells. The expression of certain genes that directly control the rate of key metabolic pathways …

Mathematical models of the cellular metabolism have become an essential tool for the
optimization of biotechnological processes. They help to obtain a systemic understanding of …

Fluctuations in oxygen tension during tissue remodeling impose a major metabolic
challenge in human tumors. Stem-like tumor cells in glioblastoma, the most common …

Although oligodendrocytes constitute a significant proportion of cells in the central nervous
system (CNS), little is known about their intermediary metabolism. We have, therefore …

Background Toll-like receptor 4 (TLR4) plays a pivotal role in the pathophysiology of stroke-
induced inflammation. Both astroglia and microglia express TLR4, and endogenous ligands …

Reaction rates or metabolic fluxes reflect the integrated phenotype of genome, transcriptome
and proteome interactions, including regulation at all levels of the cellular hierarchy …