▪ Abstract This review summarizes key aspects of tetraspanin proteins, with a focus on the
functional relevance and structural features of these proteins and how they are organized …

Exciting new findings have emerged about the structure, function and biochemistry of
tetraspanin proteins. Five distinct tetraspanin regions have now been delineated linking …

Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease, cirrhosis and
hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide …

HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1)
are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on …

Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially
effective and a vaccine does not exist. Development of more effective therapies has been …

Plasmodium sporozoites are transmitted through the bite of infected mosquitoes and first
invade the liver of the mammalian host, as an obligatory step of the life cycle of the malaria …

Relatively little attention has been given to the large family of abundantly expressed
transmembrane proteins known as tetraspanins. Now, the importance of tetraspanins is …

Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver
disease. Recently, based on a genotype 2a isolate, tissue culture systems supporting …

ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV);
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …

Human CD81, a known receptor for hepatitis C virus envelope E2 glycoprotein, is a
transmembrane protein belonging to the tetraspanin family. The crystal structure of human …