Prenatal treatment with the antiepileptic drug valproic acid (VPA) is associated with a
significant risk of somatic anomalies, neurodevelopmental delays, and 7–10× increase in …

Clinical findings show that the use of valproic acid (VPA) during pregnancy increases the
risk of birth defects and autism spectrum disorder in offspring. Although there is a consensus …

This study assessed apoptosis in the offspring of rats exposed to oxcarbazepine (OXC) from
day 7 to 15 of gestation. Three groups of pregnant Wistar rats were used: 1) Control, treated …

Introduction: Hydrocephalus is a disorder in which the circulation of cerebrospinal fluid is
altered in a manner that leads to its accumulation in the ventricles and subarachnoid space …

Esta revisão teve como objetivos apresentar os principais parâmetros empregados para a
avaliação de neurotoxicidade durante o período inicial da vida de roedores até a …

Adolescence is a developmental period second to infancy in terms of the rate of
developmental changes that can occur within the brain (Arain et al., 2013), with an …

Esta revisão teve como objetivos apresentar os principais parâmetros empregados para a
avaliação de neurotoxicidade durante o período inicial da vida de roedores até a …

Positive social interactions and successful relationships are important for physical and
mental health, and have been shown to elicit beneficial effects on multiple physiological …

Neural tube defects (NTDs) are the major congenital malformations of the central nervous
system in humans. The commonest forms of NTDs in humans are spinal bifida and …