The biology and evolution of spider venoms
Spiders are diverse, predatory arthropods that have inhabited Earth for around 400 million
years. They are well known for their complex venom systems that are used to overpower …
years. They are well known for their complex venom systems that are used to overpower …
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
HA Lashuel, PT Lansbury - Quarterly reviews of biophysics, 2006 - cambridge.org
1. Introduction 22. What is the significance of the shared structural properties of disease-
associated protein fibrils? 32.1 Mechanism of amyloid fibril formation in vitro 62.1. 1 In vitro …
associated protein fibrils? 32.1 Mechanism of amyloid fibril formation in vitro 62.1. 1 In vitro …
[图书][B] Three-dimensional electron microscopy of macromolecular assemblies: visualization of biological molecules in their native state
J Frank - 2006 - books.google.com
Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …
biophysics and structural biology at present, and Frank is arguably the most distinguished …
Different species of α-synuclein oligomers induce calcium influx and seeding
KM Danzer, D Haasen, AR Karow… - Journal of …, 2007 - Soc Neuroscience
Aggregation of α-synuclein (α-syn) has been linked to the pathogenesis of Parkinson's
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …
Negative staining and image classification—powerful tools in modern electron microscopy
Vitrification is the state-of-the-art specimen preparation technique for molecular electron
microscopy (EM) and therefore negative staining may appear to be an outdated approach. In …
microscopy (EM) and therefore negative staining may appear to be an outdated approach. In …
Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease
MJ Volles, SJ Lee, JC Rochet, MD Shtilerman… - Biochemistry, 2001 - ACS Publications
Fibrillar α-synuclein is a component of the Lewy body, the characteristic neuronal inclusion
of the Parkinson's disease (PD) brain. Both α-synuclein mutations linked to autosomal …
of the Parkinson's disease (PD) brain. Both α-synuclein mutations linked to autosomal …
The adhesion GPCR latrophilin/CIRL shapes mechanosensation
N Scholz, J Gehring, C Guan, D Ljaschenko, R Fischer… - Cell reports, 2015 - cell.com
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control
cellular states in response to soluble extracellular cues. However, the modality of stimuli …
cellular states in response to soluble extracellular cues. However, the modality of stimuli …
[HTML][HTML] Structural and functional imaging with carbon nanotube AFM probes
Atomic force microscopy (AFM) has great potential as a tool for structural biology, a field in
which there is increasing demand to characterize larger and more complex biomolecular …
which there is increasing demand to characterize larger and more complex biomolecular …
The black widow spider genus Latrodectus (Araneae: Theridiidae): phylogeny, biogeography, and invasion history
The spider genus Latrodectus includes the widely known black widows, notorious because
of the extreme potency of their neurotoxic venom. The genus has a worldwide distribution …
of the extreme potency of their neurotoxic venom. The genus has a worldwide distribution …
Structure and pharmacology of spider venom neurotoxins
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular
mass organic molecules. Their neurotoxic activity is due to the interaction of the venom …
mass organic molecules. Their neurotoxic activity is due to the interaction of the venom …