Autoimmunity and organ damage in systemic lupus erythematosus
GC Tsokos - Nature immunology, 2020 - nature.com
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …
almost every aspect of the immune system contributes to the expression of systemic …
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …
heritability, shows differences in prevalence, severity and age of onset among different …
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
Explaining the genetics of many diseases is challenging because most associations localize
to incompletely characterized regulatory regions. Using new computational methods, we …
to incompletely characterized regulatory regions. Using new computational methods, we …
Transancestral mapping and genetic load in systemic lupus erythematosus
CD Langefeld, HC Ainsworth, DSC Graham… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …
ethnic disparities. We report a large transancestral association study of SLE using …
Analyzing and interpreting genome data at the network level with ConsensusPathDB
ConsensusPathDB consists of a comprehensive collection of human (as well as mouse and
yeast) molecular interaction data integrated from 32 different public repositories and a web …
yeast) molecular interaction data integrated from 32 different public repositories and a web …
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations
J Dai, J Lv, M Zhu, Y Wang, N Qin, H Ma… - The Lancet …, 2019 - thelancet.com
Background Genetic variation has an important role in the development of non-small-cell
lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully …
lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully …
Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …
The pathogenesis of systemic lupus erythematosus: harnessing big data to understand the molecular basis of lupus
MD Catalina, KA Owen, AC Labonte, AC Grammer… - Journal of …, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease that causes
damage to multiple organ systems. Despite decades of research and available murine …
damage to multiple organ systems. Despite decades of research and available murine …
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
E Ricker, M Manni, D Flores-Castro, D Jenkins… - Nature …, 2021 - nature.com
Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …