Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012) |
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With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a
vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of …

Neurodegenerative diseases (NDs) represent a common neurological pathology that
determines a progressive deterioration of the brain or the nervous system. For treating NDs …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …

P-Glycoprotein (Pgp) is one of the best characterized ABC transporters, often involved in the
multidrug-resistance phenotype overexpressed by several cancer cell lines. Experimental …

Abstract ABCB1 (P-glycoprotein/P-gp) is an ATP-binding cassette transporter well known for
its association with multidrug resistance in cancer cells. Powered by the hydrolysis of ATP, it …

P-Glycoprotein (P-gp) is often involved in multidrug resistance (MDR) to the
pharmacological action of a wide number of anticancer agents. In this article, a series of …

Modulation of drug transporters via herbal medicines which have been widely used in
combination with conventional prescription drugs may result in herb–drug interactions in …

Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane,
terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of …

Lathyrane diterpenoids are one of the primary types of secondary metabolites present in the
genus Euphorbia and one of the largest groups of diterpenes. They are characterized by …