Abstract On March 11, 2020, the World Health Organization (WHO) declared COVID-19 a
pandemic. The outbreak caused a worldwide impact, becoming a health threat to the …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Fishes respond to different abiotic and biotic stressors through changes in gene expression
as a part of an integrated physiological response. Transcriptomics approaches have been …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

Fish faced with stressful stimuli launch an endocrine stress response through activation of
the hypothalamic-pituitary-interrenal (HPI-) axis to release cortisol into the blood …

Background Scales are mineralised exoskeletal structures that are part of the dermal
skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony …

Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

Glucocorticoid hormones (GCs) have profound effects on bone metabolism. Via their nuclear
hormone receptor–the GR–they act locally within bone cells and modulate their proliferation …