Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality
of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and …

Background Notalgia paresthetica is a neuropathic disorder characterized by pruritus in a
circumscribed region of the upper back. Difelikefalin, a selective kappa opioid receptor …

Migraine is a leading cause of disability worldwide. Despite the recent approval of several
calcitonin gene-related peptide-targeted therapies, many people with migraine do not …

Background Pruritus is the most common and burdensome symptom of atopic dermatitis
(AD). Pruritus-targeted treatments in AD are lacking, particularly for patients with milder skin …

Rationale & Objective We report a pooled safety analysis of intravenous difelikefalin in
participants with moderate to severe chronic kidney disease–associated pruritus (CKD-aP) …

Background Difelikefalin, a peripherally specific selective agonist of kappa opioid receptors,
has been approved for the treatment of pruritus in hemodialysis patients in the United States …

Background Chronic kidney disease-associated pruritus (CKD-aP) is associated with an
increased risk of depression, poor sleep and reduced health-related quality of life. Two …

Background Poor sleep quality is associated with higher mortality and lower quality of life in
patients with chronic kidney disease–associated pruritus (CKD-aP). Difelikefalin reduces …

El prurito asociado a la enfermedad renal crónica (Pa-ERC) es una de las comorbilidades
más comunes e incapacitantes en los pacientes con ERC avanzada. Además, está …

The availability of this targeted therapy, coupled with a new understanding of the impact
pruritus has on our patients, has the potential to significantly improve the lives of patients …