[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
B Magnuson, B Ekim, DC Fingar - Biochemical Journal, 2012 - portlandpress.com
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …
AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …
PKA: lessons learned after twenty years
The first protein kinase structure, solved in 1991, revealed the fold that is shared by all
members of the eukaryotic protein kinase superfamily and showed how the conserved …
members of the eukaryotic protein kinase superfamily and showed how the conserved …
mTOR signaling in protein translation regulation: implications in cancer genesis and therapeutic interventions
M Showkat, MA Beigh, KI Andrabi - Molecular biology …, 2014 - Wiley Online Library
mTOR is a central nutrient sensor that signals a cell to grow and proliferate. Through distinct
protein complexes it regulates different levels of available cellular energy substrates …
protein complexes it regulates different levels of available cellular energy substrates …
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Skeletal muscles comprise a substantial portion of whole body mass and are integral for
locomotion and metabolic health. Increasing age is associated with declines in both muscle …
locomotion and metabolic health. Increasing age is associated with declines in both muscle …
Regulation of muscle protein synthesis and the effects of catabolic states
BS Gordon, AR Kelleher, SR Kimball - … journal of biochemistry & cell biology, 2013 - Elsevier
Protein synthesis and degradation are dynamically regulated processes that act in concert to
control the accretion or loss of muscle mass. The present article focuses on the mechanisms …
control the accretion or loss of muscle mass. The present article focuses on the mechanisms …
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
AGC kinases, mechanisms of regulation and innovative drug development
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG …
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1
Protein synthesis has a key role in the control of cell proliferation, and its deregulation is
associated with pathological conditions, notably cancer. Rapamycin, an inhibitor of …
associated with pathological conditions, notably cancer. Rapamycin, an inhibitor of …