Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Pansclerotic morphea (PSM) is a rare, devastating disease characterized by extensive soft
tissue fibrosis, secondary contractions, and significant morbidity. PSM pathogenesis is …

Patients with rare and complex rheumatic diseases (RDs) present with immense clinical
variability inherent to all immunologic diseases. In addition to systemic and organ‐specific …

The past 25 years have seen major novel developments in the field of paediatric
rheumatology. The concept of autoinflammation was introduced to this field, and medicine …

Inborn errors of immunity (IEIs) comprise a variety of immune conditions leading to
infections, autoimmunity, allergy, and cancer. Some IEIs have no identified mutation (s) …

Background Inborn errors of immunity (IEI) with dysregulated JAK/STAT signaling present
with variable manifestations of immune dysregulation and infections. Hematopoietic stem …

Cells execute biological functions to support phenotypes such as growth, migration, and
secretion. Complementarily, each function of a cell has resource costs that constrain …

Signal transducer and activator of transcription (STAT)-6 is a transcription factor central to
pro-allergic immune responses, although the function of human STAT6 at the whole …

Abstract Signal Transducer and Activator of Transcription (STAT) proteins play pivotal roles
in immune regulation. The dysregulation of these proteins, attributed to both gain-of-function …