Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and
transient decrease in kidney function. AKI is part of an array of conditions collectively defined …

Acute kidney injury in patients who suffer a malignancy is a common complication. Due to its
high prevalence and effective treatment, one of the most frequent causes that both …

Objectives The combination of immune-checkpoint inhibitors (ICI) and platinum-pemetrexed
chemotherapy (CT) in first-line setting improved survival outcomes of advanced non-small …

Karyomegalic interstitial nephropathy (KIN) has been reported as an incidental finding in
patients with childhood cancer treated with ifosfamide. It is defined by the presence of …

Scientific databases were searched for terms applicable to karyomegaly in renal tubules of
laboratory animals used in preclinical safety evaluation studies, and in humans. Renal …

Rationale and Objective The incidence of kidney disease is high in patients after allogeneic
hematopoietic cell transplantation (aHCT). Although rarely performed, kidney biopsy may be …

Approximately 20 to 40% of patients with type 1 or type 2 diabetes develop diabetic kidney
disease. It is a clinical syndrome characterized by persistent albuminuria (> 300mg/24h, or …

Patients with ifosfamide-induced renal damage present with Fanconi syndrome.
Karyomegalic nephropathy/interstitial nephritis (KNIN) is a rare form of chronic tubulo …

Karyomegalic interstitial nephritis (KIN) is a rare genetic kidney disease associated with a
mutation in FAN1 gene and is often underdiagnosed. The histomorphology demonstrates …

Ifosfamide is a cytotoxic drug usually used in malignant sarcomas. The nephrotoxicity of this
agent has been described essentially among children, revealed by renal failure and …