Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The genomes of all organisms throughout the tree of life are compacted and organized in
chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which …

Prokaryotic Argonaute proteins acquire guide strands derived from invading or mobile
genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

Thermoacidophilic archaea belonging to the order Sulfolobales thrive in extreme biotopes,
such as sulfuric hot springs and ore deposits. These microorganisms have been model …

Genomes of all organisms are persistently threatened by endogenous and exogenous
assaults. Bacterial mechanisms of genome maintenance must provide protection throughout …

In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B
that assemble into octameric nucleosome particles. Archaeal histones are dimeric and …

Archaea are key players in many critical ecological processes. In comparison to eukaryotes
and bacteria, however, our understanding of both the cell biology and diversity of archaea …