The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

The complement (C) inflammatory cascade is part of the phylogenetically ancient innate
immune response and is crucial to our natural ability to ward off infection. It has three critical …

The complement (C) system is a key component of innate immunity, playing a central role in
defence against microorganisms and in the processing of immune complexes. It is also a …

The search for reliable marker molecules discriminating between human Th1 and Th2 cells
identified a gene encoding a novel member of the G protein-coupled leukocyte …

In the last few years, there has been increasing interest in the physiological role of acylation-
stimulating protein (ASP). Recent studies in rats and mice, in particular in C3 (−/−) mice that …

Cell death and release of proinflammatory mediators contribute to mortality during sepsis.
Specifically, caspase-11–dependent cell death contributes to pathology and decreases in …