Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …

Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials.
Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in …