After cardiovascular diseases, infectious diseases are the second most common cause of
death worldwide. Although these infections are caused mainly by viruses or bacteria, a …

The importance of the microbiome to human health is increasingly recognized and has
become a major focus of recent research. However, much of the work has focused on a few …

Many microbial communities, including those involved in chronic human infections, are
patterned at the micron scale. In this Review, we summarize recent work that has defined the …

Candida albicans is abundant in the human gut mycobiota but this species does not
colonize the mouse gastrointestinal tract. C. albicans administration in dextran-sulfate …

To fight infections, macrophages undergo a metabolic shift whereby increased glycolysis
fuels antimicrobial inflammation and killing of pathogens. Here we demonstrate that the …

Fungal cells change shape in response to environmental stimuli, and these morphogenic
transitions drive pathogenesis and niche adaptation. For example, dimorphic fungi switch …

Infections that involve interkingdom microbial communities, such as those between bacteria
and yeast pathogens, are difficult to treat, associated with worse patient outcomes, and may …

It is well known that the opportunistic pathogenic yeast, Candida albicans, can form
polymicrobial biofilms with a variety of bacteria, both in vitro and in vivo, and that these …

Candida albicans is one of the most common human fungal pathogens. C. albicans
pathogenesis is tightly linked to its ability to under a morphogenetic transition from typically …

Mixed-species biofilm is one of the most frequently recorded clinical problems. Mixed
biofilms develop as a result of interactions between microorganisms of a single or multiple …