Glyoxal in foods: Formation, metabolism, health hazards, and its control strategies

M Zhang, C Huang, J Ou, F Liu, S Ou… - Journal of Agricultural …, 2024 - ACS Publications
Glyoxal is a highly reactive aldehyde widely present in common diet and environment and
inevitably generated through various metabolic pathways in vivo. Glyoxal is easily produced …

[HTML][HTML] AGE-RAGE axis culminates into multiple pathogenic processes: A central road to neurodegeneration

R Bhattacharya, MR Alam, MA Kamal… - Frontiers in Molecular …, 2023 - frontiersin.org
Advanced glycation end-products (AGEs; eg, glyoxal, methylglyoxal or carboxymethyl-
lysine) are heterogenous group of toxic compounds synthesized in the body through both …

Glycosylation and binding of α-dicarbonyl compounds and human serum albumin based on spectral analysis and molecular simulation

J Wu, X Hong, X Hu, D Gong, G Zhang - Journal of Molecular Structure, 2024 - Elsevier
As a highly active glycosylation intermediate, α-dicarbonyl compounds (α-DCs) would
further undergo non-enzymatic cross-linked glycosylation with proteins, leading to the …

Dual effects of dietary carnosine during in vitro digestion of a Western meal model with added ascorbic acid

YY Li, V Yaylayan, MF Palin, TM Ngapo… - Journal of Food …, 2024 - Wiley Online Library
The beneficial role of carnosine during in vitro digestion of meat was previously
demonstrated, and it was hypothesized that such benefits could also be obtained in a meal …

[HTML][HTML] Organosulfurs, S-allyl cysteine and N-acetyl cysteine sequester di-carbonyls and reduces carbonyl stress in HT22 cells

R Bhattacharya, S Saini, S Ghosh, P Roy, N Ali… - Scientific Reports, 2023 - nature.com
Diabetes, characterized by high blood glucose level, is a progressive metabolic disease that
leads to serious health complications. One of the major pathological consequences …

Glycated LDL generates reactive species that damage cell components, oxidize hemoglobin and alter surface morphology in human erythrocytes

MJ Wani, A Arif, KA Salman, R Mahmood - International Journal of …, 2024 - Elsevier
Low-density lipoprotein (LDL) transports cholesterol to various tissues via the blood.
Glycation of LDL occurs during hyperglycemic condition which is characterised by …