Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease
V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …
devastating and widespread diseases worldwide, mainly affecting the aging population. One …
CH–π hydrogen bonds in biological macromolecules
M Nishio, Y Umezawa, J Fantini, MS Weiss… - Physical Chemistry …, 2014 - pubs.rsc.org
This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …
Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes
E Sezgin, I Levantal, G Schwarzmann, V Mueller… - Biophysical …, 2012 - cell.com
296a Monday, February 27, 2012 counterparts remains unknown, especially of lipids such
as sphingolipids that, when unlabeled, enter ''raft''domains in model systems, termed …
as sphingolipids that, when unlabeled, enter ''raft''domains in model systems, termed …
[HTML][HTML] Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes
Soluble Aβ oligomers contribute importantly to synaptotoxicity in Alzheimer's disease, but
their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were …
their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were …
Shiga toxins
J Bergan, ABD Lingelem, R Simm, T Skotland… - Toxicon, 2012 - Elsevier
Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain
strains of Escherichia coli. There is currently no available treatment for disease caused by …
strains of Escherichia coli. There is currently no available treatment for disease caused by …
Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor
Cholesterol influences ion-channel function, distribution and clustering in the membrane,
endocytosis and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report …
endocytosis and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report …
Lipid Rafts: Linking Alzheimer′s Amyloid‐β Production, Aggregation, and Toxicity at Neuronal Membranes
JV Rushworth, NM Hooper - International journal of Alzheimer's …, 2011 - Wiley Online Library
Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into
which specific subsets of proteins and lipids partition, creating cell‐signalling platforms that …
which specific subsets of proteins and lipids partition, creating cell‐signalling platforms that …
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
NJ Haughey, VVR Bandaru, M Bae… - Biochimica et Biophysica …, 2010 - Elsevier
Sphingolipids in the membranes of neurons play important roles in signal transduction,
either by modulating the localization and activation of membrane-associated receptors or by …
either by modulating the localization and activation of membrane-associated receptors or by …