The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

296a Monday, February 27, 2012 counterparts remains unknown, especially of lipids such
as sphingolipids that, when unlabeled, enter ''raft''domains in model systems, termed …

Soluble Aβ oligomers contribute importantly to synaptotoxicity in Alzheimer's disease, but
their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were …

Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain
strains of Escherichia coli. There is currently no available treatment for disease caused by …

Although cell membranes are packed with proteins mingling with lipids, remarkably little is
known about how proteins interact with lipids to carry out their function. Novel analytical …

Cholesterol influences ion-channel function, distribution and clustering in the membrane,
endocytosis and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report …

Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into
which specific subsets of proteins and lipids partition, creating cell‐signalling platforms that …

Sphingolipids in the membranes of neurons play important roles in signal transduction,
either by modulating the localization and activation of membrane-associated receptors or by …