[HTML][HTML] Energy metabolism in the liver
L Rui - Comprehensive physiology, 2014 - ncbi.nlm.nih.gov
The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …
[HTML][HTML] Signalling by insulin and IGF receptors: supporting acts and new players
K Siddle - Journal of molecular endocrinology, 2011 - jme.bioscientifica.com
The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their
diverse effects on cellular metabolism, growth and survival are well established in broad …
diverse effects on cellular metabolism, growth and survival are well established in broad …
The human and mouse complement of SH2 domain proteins—establishing the boundaries of phosphotyrosine signaling
BA Liu, K Jablonowski, M Raina, M Arcé, T Pawson… - Molecular cell, 2006 - cell.com
SH2 domains are interaction modules uniquely dedicated to the recognition of
phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to …
phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to …
Chromosomal deletions on 16p11. 2 encompassing SH2B1 are associated with accelerated metabolic disease
New approaches are needed to treat people whose obesity and type 2 diabetes (T2D) are
driven by specific mechanisms. We investigate a deletion on chromosome 16p11. 2 …
driven by specific mechanisms. We investigate a deletion on chromosome 16p11. 2 …
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
D Ren, M Li, C Duan, L Rui - Cell metabolism, 2005 - cell.com
Leptin regulates energy balance and body weight by activating its receptor LEPRb and
multiple downstream signaling pathways, including the STAT3 and the IRS2/PI 3-kinase …
multiple downstream signaling pathways, including the STAT3 and the IRS2/PI 3-kinase …
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
SH2B1 (previously named SH2-B), a cytoplasmic adaptor protein, binds via its Src homology
2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin …
2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin …
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
K Siddle - Frontiers in endocrinology, 2012 - frontiersin.org
Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …
Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease
Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight
loss; however, the underlying molecular mechanism remains elusive. Here, we uncover …
loss; however, the underlying molecular mechanism remains elusive. Here, we uncover …
Grb10 and Grb14: enigmatic regulators of insulin action–and more?
The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute
a family of structurally related multidomain adapters with diverse cellular functions. Grb10 …
a family of structurally related multidomain adapters with diverse cellular functions. Grb10 …
Genes and longevity of lifespan
Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …