Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Adoptive immunotherapy with natural killer cells was pioneered 30 years ago in human
clinical trials with the development of cytokine‐induced killer cells—unfractionated …

Simple Summary The tumor microenvironment (TME) is a complicated network composed of
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …

Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

Clinical success of chimeric antigen receptor (CAR) T cell immunotherapy requires the
engineering of autologous T cells, which limits the broader implementation of CAR cell …

Triple‐negative breast cancer (TNBC) exhibits resistance to conventional treatments due to
the presence of cancer stem cells (CSCs), causing postsurgical relapse and a dismal …

Myeloid-derived suppressor cells (MDSCs) are immune cells of the myeloid lineage that
progressively accumulate in tumors and play an important role in promoting tumor growth …

Background: Chimeric antigen receptor (CAR)-modified T cells have successfully harnessed
T cell immunity against malignancies, but they are by no means the only cell therapies in …

Natural Killer (NK) cells are a top contender in the development of adoptive cell therapies for
cancer due to their diverse antitumor functions and ability to restrict their activation against …