The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
The immunology of atherosclerosis
A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …
population and among patients with chronic kidney disease (CKD). In most cases, the …
Genome-wide association study of peripheral artery disease in the Million Veteran Program
D Klarin, J Lynch, K Aragam, M Chaffin, TL Assimes… - Nature medicine, 2019 - nature.com
Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality;
however, the extent to which genetic factors increase risk for PAD is largely unknown. Using …
however, the extent to which genetic factors increase risk for PAD is largely unknown. Using …
The immune system in atherosclerosis
GK Hansson, A Hermansson - Nature immunology, 2011 - nature.com
Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …
Atherosclerosis in rheumatoid arthritis: is it all about inflammation?
S Skeoch, IN Bruce - Nature Reviews Rheumatology, 2015 - nature.com
Rheumatoid arthritis (RA) has long been associated with increased cardiovascular risk, but
despite substantial improvements in disease management, mortality remains high …
despite substantial improvements in disease management, mortality remains high …
The immune response in atherosclerosis: a double-edged sword
GK Hansson, P Libby - Nature reviews immunology, 2006 - nature.com
Immune responses participate in every phase of atherosclerosis. There is increasing
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …
Functions of NOD-like receptors in human diseases
Y Zhong, A Kinio, M Saleh - Frontiers in immunology, 2013 - frontiersin.org
Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …
Inflammation and atherosclerosis
GK Hansson, AKL Robertson… - Annu. Rev. Pathol …, 2006 - annualreviews.org
Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …
Regulation of MHC class II gene expression by the class II transactivator
W Reith, S LeibundGut-Landmann… - Nature Reviews …, 2005 - nature.com
MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …
The NLR family of innate immune and cell death sensors
B Sundaram, RE Tweedell, SP Kumar, TD Kanneganti - Immunity, 2024 - cell.com
Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …