The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

Peripheral artery disease (PAD) is a leading cause of cardiovascular morbidity and mortality;
however, the extent to which genetic factors increase risk for PAD is largely unknown. Using …

Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by
atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis …

Rheumatoid arthritis (RA) has long been associated with increased cardiovascular risk, but
despite substantial improvements in disease management, mortality remains high …

Immune responses participate in every phase of atherosclerosis. There is increasing
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …