Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

In vitro models of liver (patho) physiology, new technologies, and experimental approaches
are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells …

Background & Aims Liver stiffness is increased in advanced chronic liver disease (ACLD)
and accurately predicts prognosis in this population. Recent data suggest that extracellular …

Abstract Background & Aims Portal hypertension (PH) is a frequent and severe clinical
syndrome associated with chronic liver disease. Considering the mechanobiological effects …

Simple Summary We define the transcriptome and secretome of primary LSECs during the
progression of cirrhosis, revealing specific molecular signatures, novel biomarkers and …

Since the first descriptions of hepatocyte-released exosome-like vesicles in 2008, the
number of publications describing Extracellular Vesicles (EVs) released by liver cells in the …

Abstract Background and Aims Portal hypertension is the main consequence of cirrhosis,
responsible for the complications defining clinical decompensation. The only cure for …

Background & Aims Glucagon-like peptide (GLP)-2 may exert antifibrotic effects on hepatic
stellate cells (HSCs). Thus, we aimed to test whether application of the GLP-2 analogue …

Liver fibrosis is a condition characterized by the accumulation of extracellular matrix (ECM)
arising from the myofibroblastic transdifferentiation of hepatic stellate cells (HSCs) occurring …

The aggravating role of long noncoding RNA (lncRNA) HOTAIR has been indicated in liver
injury caused by hepatic ischemia/reperfusion. However, under the condition of alcoholic …