Recent insights into the role of Notch signaling in tumorigenesis

KG Leong, A Karsan - Blood, 2006 - ashpublications.org
Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

The notch pathway in breast cancer progression

EN Kontomanolis, S Kalagasidou… - The Scientific World …, 2018 - Wiley Online Library
Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system.
In this review, the authors summarize the current knowledge about the impact of the Notch …

KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model

J Du, Z Yuan, Z Ma, J Song, X Xie, Y Chen - Molecular BioSystems, 2014 - pubs.rsc.org
The dynamic impact approach (DIA) represents an alternative to overrepresentation analysis
(ORA) for functional analysis of time-course experiments or those involving multiple …

Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche

R Chakrabarti, T Celià-Terrassa, S Kumar, X Hang… - Science, 2018 - science.org
INTRODUCTION The stem cell niche plays a crucial role in regulating key stem cell
properties, including self-renewal, differentiation, and cell fate change. Although stem cell …

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

M Reedijk, S Odorcic, L Chang, H Zhang, N Miller… - Cancer research, 2005 - AACR
Aberrant activation of Notch receptors has been shown to cause mammary tumors in mice.
We therefore used in situ hybridization to analyze expression of Notch ligands and receptors …

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

KG Leong, K Niessen, I Kulic, A Raouf… - The Journal of …, 2007 - rupress.org
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast
cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor …

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

J Chen, N Imanaka, JD Griffin - British journal of cancer, 2010 - nature.com
Background: Epithelial-to-mesenchymal transition (EMT) is associated with decreased
adhesion and acquisition of metastatic potential of breast cancer cells. Epithelial-to …

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

S Shao, X Zhao, X Zhang, M Luo, X Zuo, S Huang… - Molecular cancer, 2015 - Springer
Background The epithelial–mesenchymal transition (EMT) is crucial for the invasion and
metastasis of breast cancer. However, how Notch signaling regulates the EMT process and …

Intrinsically disordered proteins play diverse roles in cell signaling

SE Bondos, AK Dunker, VN Uversky - Cell Communication and Signaling, 2022 - Springer
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

A Raouf, Y Zhao, K To, J Stingl, A Delaney, M Barbara… - Cell stem cell, 2008 - cell.com
Mature mammary epithelial cells are generated from undifferentiated precursors through a
hierarchical process, but the molecular mechanisms involved, particularly in the human …