Increased glutaminolysis is now recognized as a key feature of the metabolic profile of
cancer cells, along with increased aerobic glycolysis (the Warburg effect). In this review, we …

Oxidative stress can be defined as the imbalance between cellular oxidant species
production and antioxidant capability. Reactive oxygen species (ROS) are involved in a …

Many tumors increase uptake and dependence on glucose, cystine or glutamine. These
basic observations on cancer cell metabolism have opened multiple new diagnostic and …

A handful of tumor-derived cell lines form the mainstay of cancer therapeutic development,
yielding drugs with an impact typically measured as months to disease progression. To …

Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes
the propensity of most cancer cells to take up glucose avidly and convert it primarily to …

Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …

We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a
key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione …

One of the hallmarks of cancer is metabolic deregulation. Many tumors display increased
glucose uptake and breakdown through the process of aerobic glycolysis, also known as the …

Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of
human cancers. Rb functions to inhibit cell cycle progression in part by directly disabling the …

Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is
essential for proliferation of most cancer cells, which makes glutamine an appealing target …