Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Substance P is released in the spinal cord in response to painful stimuli, but its role in
nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome …

In 1900, Sherringtongl, 92 was among the first modern neural scientists to define pain as the
psychical adjunct to an imperative protective reflex. This is a concise definition, and it …

Chronic pain is characterized by abnormal sensitivity, which is due to the generation of pain
in response to the activation of the low-threshold mechanoreceptive AP fibres that normally …

One of the most excitingdevelopmentsin pain research over the past decade has been the
recognition that activitydependent changes in the excitabilityof central neuroneshave a …

Evidence from the last several decades indicates that the excitatory amino acid glutamate
plays a significant role in nociceptive processing. Glutamate and glutamate receptors are …

Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas
the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic …

Expression of cannabinoid 1 (CB1) and vanilloid 1 (VR1) receptor proteins was studied in
adult, cultured rat dorsal root ganglion neurons. Immunostaining of CB1 receptors alone …

The tachykinin NK1 receptor is widely distributed in both the central and peripheral nervous
system. In the CNS, NK1 receptors have been implicated in various behavioural responses …