Recent advances in the treatment of various cancers have resulted in the adaptation of
several novel immunotherapeutic strategies. Notably, the recent intervention through …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

Trained immunity confers a sustained augmented response of innate immune cells to a
secondary challenge, via a process dependent on metabolic and transcriptional …

Protein lysine methylation is a critical and dynamic post-translational modification that can
regulate protein stability and function. This post-translational modification is regulated by …

Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …

High levels of mitochondrial reactive oxygen species (mROS) are linked to cancer
development, which is tightly controlled by the electron transport chain (ETC). However, the …

Simple Summary New treatments that utilize targeted therapeutic agents or invigorations of
the host immune system to destroy cancer cells are not effective against all cancers or …

MicroRNAs have emerged as key regulators in T cell development, activation, and
differentiation, with miR-181a having a prominent function. By targeting several signaling …

Down syndrome (DS) is the most common chromosomal disorder and a major cause of
intellectual disability. The genetic etiology of DS is the extra copy of chromosome 21 …

Protein arginine methyltransferases (PRMTs) catalyze protein arginine methylation and are
linked to carcinogenesis and metastasis. Some members of PRMTs have been found to …