Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

ABSTRACT Proteins of the Wiskott–Aldrich syndrome protein (WASP) family function as
nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Macropinocytosis has received increasing attention in recent years for its various roles in
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …

In macropinocytosis, cells take up micrometre-sized droplets of medium into internal
vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and …

The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is
a potential infection because some bacteria have evolved mechanisms to resist predation …

Endosomes are major protein sorting stations in cells. Endosomally localised multi-protein
complexes sort integral proteins, including signaling receptors, nutrient transporters …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …