Therapeutic potential of WKYMVm in diseases

H Ma, X Guo, Z Wang, M Han, H Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
The synthetic hexapeptide WKYMVm, screened from a synthetic peptide library, has been
identified as an agonist of FPRs with the strongest activating effect on FPR2. WKYMVm …

Development of synthetic lipoxin-A4 mimetics (sLXms): New avenues in the treatment of cardio-metabolic diseases

M de Gaetano - Seminars in Immunology, 2023 - Elsevier
Resolution of inflammation is a complex, dynamic process consisting of several distinct
processes, including inhibition of endothelial activation and leukocyte trafficking; promotion …

The N-Formyl peptide receptor 2 (FPR2) agonist MR-39 exhibits anti-inflammatory activity in LPS-stimulated organotypic hippocampal cultures

E Trojan, K Tylek, M Leśkiewicz, W Lasoń… - Cells, 2021 - mdpi.com
Accumulating evidence indicates a pivotal role for chronic inflammatory processes in the
pathogenesis of neurodegenerative and psychiatric disorders. G protein-coupled formyl …

The novel small-molecule annexin-A1 mimetic, compound 17b, elicits vasoprotective actions in streptozotocin-induced diabetic mice

SA Marshall, CX Qin, M Jelinic, K O'sullivan… - International Journal of …, 2020 - mdpi.com
The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that
play an important role in the regulation of inflammatory processes. It is well-established that …

Electrical stimulation of the auricular branch vagus nerve using random and alternating frequencies triggers a rapid onset and pronounced antihyperalgesia via …

DC Salm, VV Horewicz, F Tanaka, JK Ferreira… - Molecular …, 2023 - Springer
This study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous
vagus nerve electrical stimulation (pVNS) by comparing the effects of alternating and …

Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

W Yang, J Wang, W Wu, G Wang, J Yan, Q Liu… - Acta Pharmacologica …, 2023 - nature.com
Inflammatory bowel disease (IBD) is a global health burden whose existing treatment is
largely dependent on anti-inflammatory agents. Despite showing some therapeutic actions …

Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac Dysfunction

J Chen, S Austin-Williams, CE O'Riordan… - Journal of Innate …, 2023 - karger.com
Using a global formyl peptide receptor (Fpr) 2 knockout mouse colony, we have reported the
modulatory properties of this pro-resolving receptor in polymicrobial sepsis. Herein, we have …

The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF‐κB and CD9/gp130/STAT3 signalling pathway

J Hu, X Li, Y Chen, X Han, L Li, Z Yang… - Journal of Cellular …, 2020 - Wiley Online Library
The balance between bone formation and bone resorption is closely related to bone
homeostasis. Osteoclasts, originating from the monocyte/macrophage lineage, are the only …

Role of formyl peptide receptor 2 in steatosis of L02 cells exposed to Mono‐(2‐ethylhexyl) phthalate

X Feng, R Zhang, X Miao, X Li, J Cui… - Environmental …, 2024 - Wiley Online Library
Abstract Mono‐(2‐ethylhexyl) phthalate (MEHP) can accumulate in the liver and then lead to
hepatic steatosis, while the underlying mechanism remains unclear. Inflammation plays an …

Experimental sepsis severity score associated to mortality and bacterial spreading is related to bacterial load and inflammatory profile of different tissues

MC Gonçalves, VV Horewicz, DD Lückemeyer… - Inflammation, 2017 - Springer
Pneumonia-induced sepsis is responsible for about 50% of cases in the world. Patients who
develop severe sepsis and septic shock present organ dysfunction and elevated plasma …