Review of nanosuspension formulation and process analysis in wet media milling using microhydrodynamic model and emerging characterization methods
Y Tian, S Wang, Y Yu, W Sun, R Fan, J Shi… - International journal of …, 2022 - Elsevier
Wet media milling is a popular technology used to prepare nanosuspensions. However, the
theories and methods to guide the research on the formulation and process affecting wet …
theories and methods to guide the research on the formulation and process affecting wet …
Mechanistic modeling of wet stirred media milling for production of drug nanosuspensions
Drug nanocrystals have been used for a wide range of drug delivery platforms in the
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …
pharmaceutical industry, especially for bioavailability enhancement of poorly water-soluble …
Synthesis of submicron-sized spherical silica-coated iron nickel particles with adjustable shell thickness via swirler connector-assisted spray pyrolysis
Silica-coated iron nickel (FeNi@ SiO2) particles have attracted significant attention because
of their potential applications in electronic devices. In this work, submicron-sized spherical …
of their potential applications in electronic devices. In this work, submicron-sized spherical …
Kinetic and microhydrodynamic modeling of fenofibrate nanosuspension production in a wet stirred media mill
This study examined the impact of stirrer speed and bead material loading on fenofibrate
particle breakage during wet stirred media milling (WSMM) via three kinetic models and a …
particle breakage during wet stirred media milling (WSMM) via three kinetic models and a …
Numerical simulations of liquid-solid flows with free surface by coupling IMPS and DEM
Liquid-solid two-phase flow with free surface is a significant issue in nature and engineering
fields. In present study, an in-house solver MPSDEM-SJTU based on a fully Lagrangian …
fields. In present study, an in-house solver MPSDEM-SJTU based on a fully Lagrangian …
Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions
This study aimed to develop a practical semi-mechanistic modeling framework to predict
particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a …
particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a …
Effects of bead packing limit concentration on microhydrodynamics-based prediction of breakage kinetics in wet stirred media milling
We studied wet-milling kinetics of a drug in a stirred mill using a microhydrodynamic model
with various radial distribution functions (RDFs). An n th-order kinetics model was fitted to …
with various radial distribution functions (RDFs). An n th-order kinetics model was fitted to …
A novel particle-based approach for modeling a wet vertical stirred media mill
Modeling of wet stirred media mill processes is challenging since it requires the
simultaneous modeling of the complex multiphysics in the interactions between grinding …
simultaneous modeling of the complex multiphysics in the interactions between grinding …
A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing
We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during
the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based …
the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based …
Microhydrodynamic, Kinetic and Thermal Modeling of Wet Media Milling for Process Optimization and Intensification
G Guner - 2022 - search.proquest.com
Nanoparticle production by wet stirred media milling (WSMM) is a common method for the
formulation of poorly water-soluble drugs. While most of the studies in the WSMM literature …
formulation of poorly water-soluble drugs. While most of the studies in the WSMM literature …