Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …

Sexually dimorphic mammalian tissues, including sexual organs and the brain, contain stem
cells that are directly or indirectly regulated by sex hormones,,,,,. An important question is …

The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

In spite of the widespread abuse of androgenic steroids by athletes and recreational body-
builders, the effects of these agents on athletic performance and physical function remain …

The enzyme steroid 5α-reductase (EC 1.3. 99.5) catalyzes the NADPH-dependent reduction
of the double bond of a variety of 3-oxo-Δ4 steroids including the conversion of testosterone …

Estrogens have a profound influence on skin. The relative hypoestrogenism that
accompanies menopause exacerbates the deleterious effects of both intrinsic and …

A greater understanding of the parturition process is essential in the prevention of preterm
birth, which occurs in 12.7% of infants born in the United States annually. Cervical …

Estrogens exert a wide variety of actions on reproductive and non-reproductive functions.
These effects are mediated by slow and long lasting genomic as well as rapid and transient …

A fascinating aspect of development is the potential of sexually undifferentiated embryos to
generate male or female individuals. Our knowledge of mammalian sex determination and …