Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission
C Murphy‐Royal, J Dupuis, L Groc… - Journal of …, 2017 - Wiley Online Library
Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain
function and have been implicated in various disorders of the central nervous system. These …
function and have been implicated in various disorders of the central nervous system. These …
Establishing natural nootropics: recent molecular enhancement influenced by natural nootropic
NA Suliman, CN Mat Taib… - Evidence‐Based …, 2016 - Wiley Online Library
Nootropics or smart drugs are well‐known compounds or supplements that enhance the
cognitive performance. They work by increasing the mental function such as memory …
cognitive performance. They work by increasing the mental function such as memory …
Mechanism of positive allosteric modulators acting on AMPA receptors
Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA,
kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor …
kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor …
Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior
AC Arai, M Kessler - Current drug targets, 2007 - ingentaconnect.com
Ampakines are drugs structurally derived from aniracetam that potentiate currents mediated
by AMPA type glutamate receptors. These drugs slow deactivation and attenuate …
by AMPA type glutamate receptors. These drugs slow deactivation and attenuate …
Glutamate receptor gating
K Erreger, PE Chen, DJA Wyllie… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic
transmissions within the mammalian central nervous system (CNS). As for other ion channel …
transmissions within the mammalian central nervous system (CNS). As for other ion channel …
Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms
D Turetsky, E Garringer, DK Patneau - Journal of Neuroscience, 2005 - Soc Neuroscience
AMPA receptors play a central role in basal excitatory synaptic transmission as well as
synaptic maturation and plasticity. The transmembrane AMPA receptor regulatory protein …
synaptic maturation and plasticity. The transmembrane AMPA receptor regulatory protein …
Relative roles of different mechanisms of depression at the mouse endbulb of Held
H Yang, MA Xu-Friedman - Journal of neurophysiology, 2008 - journals.physiology.org
Several mechanisms can underlie short-term synaptic depression, including vesicle
depletion, receptor desensitization, and changes in presynaptic release probability. To …
depletion, receptor desensitization, and changes in presynaptic release probability. To …
Structural aspects of AMPA receptor activation, desensitization and deactivation
Glutamate mediates most of the excitatory neurotransmission in the mammalian central
nervous system by activating ionotropic glutamate receptors. Structural and functional …
nervous system by activating ionotropic glutamate receptors. Structural and functional …
Mechanisms underlying signal filtering at a multisynapse contact
T Budisantoso, K Matsui, N Kamasawa… - Journal of …, 2012 - Soc Neuroscience
Visual information must be relayed through the lateral geniculate nucleus before it reaches
the visual cortex. However, not all spikes created in the retina lead to postsynaptic spikes …
the visual cortex. However, not all spikes created in the retina lead to postsynaptic spikes …
Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders
S Marenco, DR Weinberger - CNS drugs, 2006 - Springer
Drugs that potentiate the activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA) receptor cause a complex cascade of consequences in experimental models …
acid (AMPA) receptor cause a complex cascade of consequences in experimental models …