Mass spectrometry-based proteomic technology and its application to study skeletal muscle cell biology

P Dowling, D Swandulla, K Ohlendieck - Cells, 2023 - mdpi.com
Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Spatial proteomics for the molecular characterization of breast cancer

K Brožová, B Hantusch, L Kenner, K Kratochwill - Proteomes, 2023 - mdpi.com
Breast cancer (BC) is a major global health issue, affecting a significant proportion of the
female population and contributing to high rates of mortality. One of the primary challenges …

Integrative AI-driven strategies for advancing precision medicine in infectious diseases and beyond: a novel multidisciplinary approach

RH Allami, MG Yousif - arXiv preprint arXiv:2307.15228, 2023 - arxiv.org
Precision medicine, tailored to individual patients based on their genetics, environment, and
lifestyle, shows promise in managing complex diseases like infections. Integrating artificial …

Protein signaling and drug target activation signatures to guide therapy prioritization: Therapeutic resistance and sensitivity in the I-SPY 2 Trial

RI Gallagher, J Wulfkuhle, DM Wolf… - Cell Reports …, 2023 - cell.com
Molecular subtyping of breast cancer is based mostly on HR/HER2 and gene expression-
based immune, DNA repair deficiency, and luminal signatures. We extend this description …

Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

S Lee, G Kim, JY Lee, AC Lee, S Kwon - Molecular Cancer, 2024 - Springer
Technologies to decipher cellular biology, such as bulk sequencing technologies and single-
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …

Microbial pathogenesis in the era of spatial omics

S Lempke, D May, SE Ewald - Infection and Immunity, 2023 - Am Soc Microbiol
The biology of a cell, whether it is a unicellular organism or part of a multicellular network, is
influenced by cell type, temporal changes in cell state, and the cell's environment. Spatial …

A comparison of tissue dissection techniques for diagnostic, prognostic, and theragnostic analysis of human disease

EM Walsh, MK Halushka - Pathobiology, 2023 - karger.com
Histopathology has historically been the critical technique for the diagnosis and treatment of
human disease. Today, genomics, transcriptomics, and proteomics from specific cells, rather …

Spatiotemporal Omics-Refining the landscape of precision medicine

J Zhang, J Yin, Y Heng, K Xie, A Chen, I Amit… - Life …, 2022 - academic.oup.com
Current streamline of precision medicine uses histomorphological and molecular
information to indicate individual phenotypes and genotypes to achieve optimal outcome of …

Laser capture microdissection: a gear for pancreatic cancer research

BH Rao, P Souček, V Hlaváč - International Journal of Molecular Sciences, 2022 - mdpi.com
The advancement in molecular techniques has been attributed to the quality and
significance of cancer research. Pancreatic cancer (PC) is one of the rare cancers with …

Advancements in oncoproteomics technologies: Treading toward translation into clinical practice

A Punetha, D Kotiya - Proteomes, 2023 - mdpi.com
Proteomics continues to forge significant strides in the discovery of essential biological
processes, uncovering valuable information on the identity, global protein abundance …