Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics

N Singh, GR Sherin, G Mugesh - Angewandte Chemie, 2023 - Wiley Online Library
Nanozymes, nanomaterials with enzyme‐mimicking activity, have attracted tremendous
interest in recent years owing to their ability to replace natural enzymes in various …

Metal toxicity links to Alzheimer's disease and neuroinflammation

TJ Huat, J Camats-Perna, EA Newcombe… - Journal of molecular …, 2019 - Elsevier
As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Superoxide dismutases and superoxide reductases

Y Sheng, IA Abreu, DE Cabelli, MJ Maroney… - Chemical …, 2014 - ACS Publications
Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells

N Singh, SK NaveenKumar… - Angewandte Chemie …, 2021 - Wiley Online Library
Nanoparticles that functionally mimic the activity of metal‐containing enzymes (metallo‐
nanozymes) are of therapeutic importance for treating various diseases. However, it is still …

Luminescent chemodosimeters for bioimaging

Y Yang, Q Zhao, W Feng, F Li - Chemical Reviews, 2013 - ACS Publications
Luminescence bioimaging offers a unique approach for visualizing morphological details of
tissues with subcellular resolution and has become a powerful tool for the manipulation and …

Metal coordination in photoluminescent sensing

Z Liu, W He, Z Guo - Chemical Society Reviews, 2013 - pubs.rsc.org
Coordination chemistry plays an essential role in the design of photoluminescent probes for
metal ions. Metal coordination to organic dyes induces distinct optical responses which …

Mutant SOD1 mediated pathogenesis of amyotrophic lateral sclerosis

SJ Kaur, SR McKeown, S Rashid - Gene, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor
neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads …

Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options

B Uttara, AV Singh, P Zamboni… - Current …, 2009 - ingentaconnect.com
Free radicals are common outcome of normal aerobic cellular metabolism. In-built
antioxidant system of body plays its decisive role in prevention of any loss due to free …

[HTML][HTML] Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

AC Elden, HJ Kim, MP Hart, AS Chen-Plotkin… - Nature, 2010 - nature.com
The causes of amyotrophic lateral sclerosis (ALS), a devastating human neurodegenerative
disease, are poorly understood, although the protein TDP-43 has been suggested to have a …

[HTML][HTML] Oxidative stress and human health

T Rahman, I Hosen, MMT Islam… - Advances in bioscience …, 2012 - scirp.org
Redox degenerative reactions of the biological system inevitably produce reactive oxygen
species (ROS) and their derivatives. Oxidative stress is the result of an imbalance in pro …