miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
The expression and function of PAX3 in development and disease
S Boudjadi, B Chatterjee, W Sun, P Vemu, FG Barr - Gene, 2018 - Elsevier
The PAX3 gene encodes a member of the PAX family of transcription factors that is
characterized by a highly conserved paired box motif. The PAX3 protein is a transcription …
characterized by a highly conserved paired box motif. The PAX3 protein is a transcription …
circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer
Y Kong, Y Li, Y Luo, J Zhu, H Zheng, B Gao, X Guo… - Molecular Cancer, 2020 - Springer
Background Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma
(PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered …
(PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered …
PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors
MB Searcy, RK Larsen IV, BT Stevens, Y Zhang… - Nature …, 2023 - nature.com
Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1
(P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS …
(P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS …
Signaling pathways in Rhabdomyosarcoma invasion and metastasis
Rhabdomyosarcoma (RMS) is an aggressive childhood mesenchymal tumor with two major
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review
JA Diaz-Perez, GP Nielsen, C Antonescu, MS Taylor… - Human pathology, 2019 - Elsevier
The classification of bone neoplasms composed of small round cells is experiencing a
transformation after the discovery of various gene fusion rearrangements that determine …
transformation after the discovery of various gene fusion rearrangements that determine …
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
H Dorado García, F Pusch, Y Bei, J von Stebut… - Nature …, 2022 - nature.com
Despite advances in multi-modal treatment approaches, clinical outcomes of patients
suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma …
suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma …
Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
CG Langdon, KE Gadek, MR Garcia, MK Evans… - Nature …, 2021 - nature.com
PTEN promoter hypermethylation is nearly universal and PTEN copy number loss occurs in~
25% of fusion-negative rhabdomyosarcoma (FN-RMS). Here we show Pten deletion in a …
25% of fusion-negative rhabdomyosarcoma (FN-RMS). Here we show Pten deletion in a …
The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The
alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic …
alveolar subtype (ARMS) is clinically more aggressive, and characterized by an oncogenic …
[HTML][HTML] PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets
Transcriptional control is a highly dynamic process that changes rapidly in response to
various cellular and extracellular cues, making it difficult to define the mechanism of …
various cellular and extracellular cues, making it difficult to define the mechanism of …