This review summarizes the mechanisms of the initiator protein DnaA in replication initiation
and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the …

Loading of the replicative DNA helicase at origins of replication is of central importance in
DNA replication. As the first of the replication fork proteins assemble at chromosomal origins …

Bacterial chromosomes are confined in submicrometer-sized nucleoids. Chromosome
organization is facilitated by nucleoid-associated proteins (NAPs), but the mechanisms of …

The Escherichia coli replication origin oriC contains the initiator ATP-DnaA-Oligomerization
Region (DOR) and its flanking duplex unwinding element (DUE). In the Left-DOR subregion …

Replication of the bacterial chromosome initiates at a single origin of replication that is
called oriC. This occurs via the concerted action of numerous proteins, including DnaA …

New antibiotics with novel modes of action are required to combat the growing threat posed
by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high …

To initiate DNA replication, DnaA recognizes and binds to specific sequences within the
Escherichia coli chromosomal origin (oriC), and then unwinds a region within oriC. Next …

To ensure proper timing of chromosome duplication during the cell cycle, bacteria must
carefully regulate the activity of initiator protein DnaA and its interactions with the unique …

In Escherichia coli, the replication origin oriC consists of two functional regions: the duplex
unwinding element (DUE) and its flanking DnaA-assembly region (DAR). ATP-DnaA …

Nucleoid-associated proteins typically are abundant, low-molecular-mass polypeptides that
bind DNA and alter its shape and its ability to participate in transactions such as …