Clinical applications of stem cell-derived exosomes
F Tan, X Li, Z Wang, J Li, K Shahzad… - Signal Transduction and …, 2024 - nature.com
Although stem cell-based therapy has demonstrated considerable potential to manage
certain diseases more successfully than conventional surgery, it nevertheless comes with …
certain diseases more successfully than conventional surgery, it nevertheless comes with …
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
Extracellular vesicles in cardiovascular disease: biological functions and therapeutic implications
Extracellular vesicles (EVs), including exosomes and microvesicles, are lipid bilayer
particles naturally released from the cell. While exosomes are formed as intraluminal …
particles naturally released from the cell. While exosomes are formed as intraluminal …
Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …
as delivery vehicles for molecular messages. During the last decade, EVs have been …
Association of systemic immune inflammation index with all-cause, cardiovascular disease, and cancer-related mortality in patients with cardiovascular disease: a …
S Xiao, Z Wang, R Zuo, Y Zhou, Y Yang… - Journal of …, 2023 - Taylor & Francis
Objective Our research was designed to investigate the relationship between systemic
immune inflammation (SII) index and all-cause, cardiovascular disease (CVD), and cancer …
immune inflammation (SII) index and all-cause, cardiovascular disease (CVD), and cancer …
Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death …
Human pluripotent stem cells (hPSCs)-derived cardiovascular progenitor cells (CVPCs) are
a promising source for myocardial repair, while the mechanisms remain largely unknown …
a promising source for myocardial repair, while the mechanisms remain largely unknown …
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs–EVOLVE …
Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial
investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate …
investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate …
Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability
C Chi, H Fu, YH Li, GY Zhang, FY Zeng… - European Heart …, 2022 - academic.oup.com
Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain
largely unknown. This study sought to investigate the role of fibronectin type-III domain …
largely unknown. This study sought to investigate the role of fibronectin type-III domain …
Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review
This paper aims to provide an important update on the recent preclinical and clinical trials
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
using cell therapy strategies and engineered heart tissues for the treatment of postinfarction …
Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations
Ischemic diseases characterized by an insufficient blood flow that leads to a decrease in
oxygen and nutrient uptake by cells have emerged as an important contributor to both …
oxygen and nutrient uptake by cells have emerged as an important contributor to both …