The discovery and development of liraglutide and semaglutide
LB Knudsen, J Lau - Frontiers in endocrinology, 2019 - frontiersin.org
The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
The thiol pool in human plasma: the central contribution of albumin to redox processes
L Turell, R Radi, B Alvarez - Free Radical Biology and Medicine, 2013 - Elsevier
The plasma compartment has particular features regarding the nature and concentration of
low and high molecular weight thiols and oxidized derivatives. Plasma is relatively poor in …
low and high molecular weight thiols and oxidized derivatives. Plasma is relatively poor in …
Spectroscopy and molecular simulation on the interaction of Nano-Kaempferol prepared by oil-in-water with two carrier proteins: An investigation of protein–protein …
M Kaffash, S Tolou-Shikhzadeh-Yazdi… - … Acta Part A: Molecular …, 2024 - Elsevier
In this work, the interaction of human serum albumin (HSA) and human holo-transferrin
(HTF) with the prepared Nano-Kaempferol (Nano-KMP) through oil-in-water procedure was …
(HTF) with the prepared Nano-Kaempferol (Nano-KMP) through oil-in-water procedure was …
Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide
J Lau, P Bloch, L Schäffer, I Pettersson… - Journal of medicinal …, 2015 - ACS Publications
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum
albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The …
albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The …
Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy
Albumin is the most abundant circulating protein in plasma and has recently emerged as a
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …
Serum protein-based nanoparticles for cancer diagnosis and treatment
Serum protein as naturally essential biomacromolecules has recently emerged as a
versatile carrier for diagnostic and therapeutic drug delivery for cancer nanomedicine with …
versatile carrier for diagnostic and therapeutic drug delivery for cancer nanomedicine with …
Structural basis of the drug-binding specificity of human serum albumin
J Ghuman, PA Zunszain, I Petitpas… - Journal of molecular …, 2005 - Elsevier
Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide
range of drugs, thereby restricting their free, active concentrations. The problem of …
range of drugs, thereby restricting their free, active concentrations. The problem of …
High resolution NMR spectroscopy as a structural and analytical tool for unsaturated lipids in solution
E Alexandri, R Ahmed, H Siddiqui, MI Choudhary… - Molecules, 2017 - mdpi.com
Mono-and polyunsaturated lipids are widely distributed in Nature, and are structurally and
functionally a diverse class of molecules with a variety of physicochemical, biological …
functionally a diverse class of molecules with a variety of physicochemical, biological …
Practical aspects of the ligand-binding and enzymatic properties of human serum albumin
U Kragh-Hansen, VTG Chuang… - Biological and …, 2002 - jstage.jst.go.jp
Recent work with approaches like recombinant mutants and X-ray crystallography has given
much new information about the ligand-binding properties of human serum albumin (HSA) …
much new information about the ligand-binding properties of human serum albumin (HSA) …
Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin
AA Bhattacharya, T Grüne, S Curry - Journal of molecular biology, 2000 - Elsevier
Human serum albumin (HSA) is an abundant plasma protein that is responsible for the
transport of fatty acids. HSA also binds and perturbs the pharmacokinetics of a wide range of …
transport of fatty acids. HSA also binds and perturbs the pharmacokinetics of a wide range of …