Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
Medicinal importance, coordination chemistry with selected metals (Cu, Ag, Au) and chemosensing of thiourea derivatives. A review
Thiourea and its derivatives are versatile compounds used in several fields of life ranging
from medicinal to chemosensor applications. In this review article, generally used …
from medicinal to chemosensor applications. In this review article, generally used …
Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design …
A Ragab, SA Fouad, YA Ammar, DS Aboul-Magd… - Antibiotics, 2023 - mdpi.com
Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …
Identification of a new class of potent aldose reductase inhibitors: design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines
Aldose reductase (AR) acts as a multi-disease target for the design and development of
therapeutic agents for the management of diabetic complications as well as non-diabetic …
therapeutic agents for the management of diabetic complications as well as non-diabetic …
Rational design of novel pyridine-based drugs candidates for lymphoma therapy
Research efforts to develop an effective drug for lymphoma with minimal side effects are still
very slow. To aid the discovery of new lymphoma drug, we led an extensive in silico …
very slow. To aid the discovery of new lymphoma drug, we led an extensive in silico …
Assessment of antidiabetic activity of the shikonin by allosteric inhibition of protein-tyrosine phosphatase 1B (PTP1B) using state of art: an in silico and in vitro tactics
Diabetes mellitus is a multifactorial disease that affects both developing and developed
countries and is a major public health concern. Many synthetic drugs are available in the …
countries and is a major public health concern. Many synthetic drugs are available in the …
Design and prediction of ADME/Tox properties of novel magnolol derivatives as anticancer agents for NSCLC using 3D-QSAR, molecular docking, MOLCAD and MM …
Introduction: In this work, we used several molecular modeling techniques to design new
molecules for the treatment of non-small cell lung cancer (NSCLC). Methods: For this …
molecules for the treatment of non-small cell lung cancer (NSCLC). Methods: For this …
New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
Design, molecular docking, synthesis, anticancer and anti-hyperglycemic assessments of thiazolidine-2, 4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR …
Newly designed thiazolidine-2, 4-diones 3–7a–c were synthesized, and their anticancer
activities were screened against three cancer lines. They showed potent activities against …
activities were screened against three cancer lines. They showed potent activities against …
Synthesis, anticancer and antitubercular properties of new chalcones and their nitrogen-containing five-membered heterocyclic hybrids bearing sulfonamide moiety
LF Castaño, J Quiroga, R Abonia, D Insuasty… - International Journal of …, 2022 - mdpi.com
A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …