Unveiling the potential of systems biology in biotechnology and biomedical research
S Saranya, L Thamanna, P Chellapandi - Systems Microbiology and …, 2024 - Springer
Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …
systems and synthetic biology developed by constraint-based metabolic simulations using …
[HTML][HTML] Genome-scale models as a vehicle for knowledge transfer from microbial to mammalian cell systems
B Strain, J Morrissey, A Antonakoudis… - Computational and …, 2023 - Elsevier
With the plethora of omics data becoming available for mammalian cell and, increasingly,
human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful …
human cell systems, Genome-scale metabolic models (GEMs) have emerged as a useful …
A Long-Term Growth Stable Halomonas sp. Deleted with Multiple Transposases Guided by Its Metabolic Network Model Halo-ecGEM
L Zhang, JW Ye, G Li, H Park, H Luo, Y Lin, S Li… - Metabolic …, 2024 - Elsevier
Microbial instability is a common problem during bio-production based on microbial hosts.
Halomonas bluephagenesis has been developed as a chassis for next generation industrial …
Halomonas bluephagenesis has been developed as a chassis for next generation industrial …
[HTML][HTML] Building blocks needed for mechanistic modeling of bioprocesses: A critical review based on protein production by CHO cells
Y González-Hernández, P Perré - Metabolic Engineering Communications, 2024 - Elsevier
This paper reviews the key building blocks needed to develop a mechanistic model for use
as an operational production tool. The Chinese Hamster Ovary (CHO) cell, one of the most …
as an operational production tool. The Chinese Hamster Ovary (CHO) cell, one of the most …
A Lifelike guided journey through the pathophysiology of pulmonary hypertension—from measured metabolites to the mechanism of action of drugs
N Weinstein, J Carlsen, S Schulz… - Frontiers in …, 2024 - frontiersin.org
Introduction Pulmonary hypertension (PH) is a pathological condition that affects
approximately 1% of the population. The prognosis for many patients is poor, even after …
approximately 1% of the population. The prognosis for many patients is poor, even after …
[PDF][PDF] Exploration of machine learning approaches with genome-scale metabolic model-generated fluxes
G Magazzu - 2023 - research.tees.ac.uk
Biology, from the ancient Greek,“study of life”, is the most fascinating yet complex of all
sciences. Its understanding is paramount in solving many current problems we face in our …
sciences. Its understanding is paramount in solving many current problems we face in our …