Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …
Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
[HTML][HTML] cGAS-STING pathway in cancer biotherapy
Y Wang, J Luo, A Alu, X Han, Y Wei, X Wei - Molecular cancer, 2020 - Springer
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor
immunity by generating type I interferons. In recent decades, we have witnessed that …
immunity by generating type I interferons. In recent decades, we have witnessed that …
Signaling by cGAS–STING in neurodegeneration, neuroinflammation, and aging
Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …
[HTML][HTML] Research advances in how the cGAS-STING pathway controls the cellular inflammatory response
D Wan, W Jiang, J Hao - Frontiers in immunology, 2020 - frontiersin.org
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
G Welch, LH Tsai - EMBO reports, 2022 - embopress.org
Neurons are highly susceptible to DNA damage accumulation due to their large energy
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
requirements, elevated transcriptional activity, and long lifespan. While newer research has …
Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological
malignancies exhibit significantly higher response rates to immunotherapies as compared …
malignancies exhibit significantly higher response rates to immunotherapies as compared …
[HTML][HTML] New insights into neuroinflammation involved in pathogenic mechanism of Alzheimer's disease and its potential for therapeutic intervention
Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50
million people worldwide with an estimated increase to 139 million people by 2050. The …
million people worldwide with an estimated increase to 139 million people by 2050. The …
High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy
Y Li, Y Cheng, Y Zhou, H Du, C Zhang, Z Zhao… - Experimental …, 2022 - Elsevier
Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …
several studies show that there are disturbances in lipid metabolism in depressed patients …
[HTML][HTML] Microglia in neurodegenerative diseases
A major feature of neurodegeneration is disruption of central nervous system homeostasis,
during which microglia play diverse roles. In the central nervous system, microglia serve as …
during which microglia play diverse roles. In the central nervous system, microglia serve as …