Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune
inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …

Ectopic lymphoid-like structures often develop at sites of inflammation where they influence
the course of infection, autoimmune disease, cancer and transplant rejection. These …

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form
one of the main branches of the immune system. As IELs are located at this critical interface …

The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic
inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) …

The lymph nodes (LNs) and spleen have an optimal structure that allows the interaction
between T cells, B cells and antigen-presenting dendritic cells (DCs) on a matrix made up by …

DCs are specialized APCs that orchestrate innate and adaptive immune responses. The
intestinal mucosa contains numerous DCs, which induce either protective immunity to …

The accuracy of 18S rRNA, β‐actin mRNA and glyceraldehyde‐3‐phosphate
dehydrogenase (GAPDH) mRNA as indicators of cell number when used for normalization …

Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal
immunity and, unlike other T cells, have been proposed to differentiate from local precursors …